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ABR

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GENERAL INFORMATION

Gene name

 ABR

Gene description

 Active BCR-related

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (U-251 MG, TIME, Daudi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA053618
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-251 MG, TIME, Daudi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

 Cytosol (approved)

Additional location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053618 A-431 Cytosol
HPA053618 U-2 OS Cytosol
HPA053618 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 ABR (HGNC Symbol)

Synonyms

 MDB

Description

 Active BCR-related (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1003518 - 1229021

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159842 (version 83.38)

Entrez gene

 29

UniProt

 Q12979 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q12979

Antibodypedia

 ABR antibodies

PROTEIN BROWSER
«
ABR-001
ABR-002
ABR-003
ABR-004
ABR-005
ABR-013
ABR-014
ABR-024
ABR-025
ABR-026
ABR-029
ABR-030
ABR-031
ABR-032
ABR-034
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABR-001
ENSP00000303909
ENST00000302538
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002692 [negative regulation of cellular extravasation]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007420 [brain development]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0032496 [response to lipopolysaccharide]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042472 [inner ear morphogenesis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043314 [negative regulation of neutrophil degranulation]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0060313 [negative regulation of blood vessel remodeling]
GO:0097190 [apoptotic signaling pathway]
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 859 aa
97.6 kDa 		No 0
ABR-002
ENSP00000461565
ENST00000574437
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 813 aa
92.4 kDa 		No 0
ABR-003
ENSP00000291107
ENST00000291107
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 822 aa
93.7 kDa 		No 0
ABR-004
ENSP00000442048
ENST00000544583
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 813 aa
92.4 kDa 		No 0
ABR-005
ENSP00000445198
ENST00000543210
Q12979 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 310 aa
35.1 kDa 		No 0
ABR-013
ENSP00000461795
ENST00000571797
I3NI05 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
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 191 aa
20.8 kDa 		No 0
ABR-014
ENSP00000459553
ENST00000572441
I3L2C0 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
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 153 aa
17.4 kDa 		No 0
ABR-024
ENSP00000458294
ENST00000574544
I3L0R7 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 189 aa
21.8 kDa 		No 0
ABR-025
ENSP00000459118
ENST00000571945
I3L1U8 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 165 aa
18.9 kDa 		No 0
ABR-026
ENSP00000437429
ENST00000536794
B7Z683 [Direct mapping]
Active breakpoint cluster region-related protein; cDNA FLJ54747, highly similar to Active breakpoint cluster region-related protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 641 aa
73.5 kDa 		No 0
ABR-029
ENSP00000460770
ENST00000575934
I3L3W0 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 133 aa
14.8 kDa 		No 0
ABR-030
ENSP00000459820
ENST00000570441
I3L2P5 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 168 aa
19.3 kDa 		No 0
ABR-031
ENSP00000459761
ENST00000570525
I3L2L3 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 88 aa
9.2 kDa 		No 0
ABR-032
ENSP00000459406
ENST00000574266
I3L259 [Direct mapping]
Active breakpoint cluster region-related protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 86 aa
9 kDa 		No 0
ABR-034
ENSP00000461629
ENST00000574139
I3L4Y1 [Direct mapping]
Active breakpoint cluster region-related protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 129 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.