Expression of CPAMD8 in cancer - Summary

CANCER ATLAS

Gene description

C3 and PZP-like, alpha-2-macroglobulin domain containing 8

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031327	HPA031328	HPA031330

GENE INFORMATION
Gene name	CPAMD8 (HGNC Symbol)
Synonyms	K-CAP, KIAA1283, VIP
Description	C3 and PZP-like, alpha-2-macroglobulin domain containing 8 (HGNC Symbol)
Entrez gene summary	CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16892947 - 17026815
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160111 (version 83.38)
Entrez gene	27151
UniProt	Q8IZJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZJ3
Antibodypedia	CPAMD8 antibodies

PROTEIN BROWSER

CPAMD8-001	CPAMD8-003	CPAMD8-009	CPAMD8-019	CPAMD8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPAMD8-001 ENSP00000402505 ENST00000443236	Q8IZJ3 [Direct mapping] C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0010951 [negative regulation of endopeptidase activity] Show all	1932 aa 211.3 kDa	No	0
CPAMD8-003 ENSP00000471545 ENST00000594249	M0R0Z5 [Direct mapping] C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	338 aa 36 kDa	No	0
CPAMD8-009 ENSP00000469163 ENST00000599287	M0QXH3 [Direct mapping] C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	175 aa 18.9 kDa	No	0
CPAMD8-019 ENSP00000473216 ENST00000598792	M0R3G7 [Direct mapping] C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.2 kDa	Yes	0
CPAMD8-201 ENSP00000373577 ENST00000388925	F8W7D1 [Direct mapping] C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	503 aa 56.1 kDa	Yes	0