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PKNOX1

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GENERAL INFORMATION

Gene name

 PKNOX1

Gene description

 PBX/knotted 1 homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
CAB004285 , HPA057215 , HPA065017
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB004285 A-431 Nucleoplasm
CAB004285 U-2 OS Nucleoplasm
CAB004285 U-251 MG Nucleoplasm
HPA057215 A-431 Nucleoplasm
Cytosol
HPA057215 RH-30 Nucleoplasm
HPA057215 U-2 OS Nucleus
Cytosol
HPA065017 PC-3 Nucleoplasm
HPA065017 RH-30 Nucleoplasm
Centrosome
HPA065017 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 PKNOX1 (HGNC Symbol)

Synonyms

 PREP1

Description

 PBX/knotted 1 homeobox 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 42974510 - 43033931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160199 (version 83.38)

Entrez gene

 5316

UniProt

 P55347 (UniProt - Evidence at protein level)

neXtProt

 NX_P55347

Antibodypedia

 PKNOX1 antibodies

PROTEIN BROWSER
PKNOX1-001
PKNOX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKNOX1-001
ENSP00000291547
ENST00000291547
P55347 [Direct mapping]
Homeobox protein PKNOX1
Q96I87 [Target identity:100%; Query identity:100%]
Homeobox-containing protein PKNOX1; PBX/knotted 1 homeobox 1; PBX/knotted 1 homeobox 1, isoform CRA_b
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001525 [angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030097 [hemopoiesis]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
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 436 aa
47.6 kDa 		No 0
PKNOX1-201
ENSP00000402243
ENST00000432907
E7EPN6 [Direct mapping]
Homeobox protein PKNOX1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
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 319 aa
34.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.