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U2AF1

GENERAL INFORMATION

Gene name

 U2AF1

Gene description

 U2 small nuclear RNA auxiliary factor 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA044833 , HPA052083
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 U2AF1 (HGNC Symbol)

Synonyms

 RN, RNU2AF1, U2AF35, U2AFBP

Description

 U2 small nuclear RNA auxiliary factor 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 43092956 - 43107587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160201 (version 83.38)

Entrez gene

 7307

UniProt

 Q01081 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01081

Antibodypedia

 U2AF1 antibodies

PROTEIN BROWSER
U2AF1-001
U2AF1-002
U2AF1-004
U2AF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
U2AF1-001
ENSP00000291552
ENST00000291552
Q01081 [Direct mapping]
Splicing factor U2AF 35 kDa subunit
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0071013 [catalytic step 2 spliceosome]
GO:0089701 [U2AF]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 240 aa
27.9 kDa 		No 0
U2AF1-002
ENSP00000369629
ENST00000380276
Q01081 [Direct mapping]
Splicing factor U2AF 35 kDa subunit
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0071013 [catalytic step 2 spliceosome]
GO:0089701 [U2AF]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 240 aa
27.9 kDa 		No 0
U2AF1-004
ENSP00000418705
ENST00000459639
Q01081 [Direct mapping]
Splicing factor U2AF 35 kDa subunit
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0071013 [catalytic step 2 spliceosome]
GO:0089701 [U2AF]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 167 aa
19.7 kDa 		No 0
U2AF1-201
ENSP00000381205
ENST00000398137
Q01081 [Direct mapping]
Splicing factor U2AF 35 kDa subunit
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0071013 [catalytic step 2 spliceosome]
GO:0089701 [U2AF]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 167 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.