Cell atlas - CRYAA - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CRYAA
Gene description	Crystallin, alpha A
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037737
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (supported)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA037737	Hep G2	Nucleoplasm
HPA037737	Hep G2	Cytosol
HPA037737	U-2 OS	Cytosol
HPA037737	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CRYAA (HGNC Symbol)
Synonyms	CRYA1, HSPB4
Description	Crystallin, alpha A (HGNC Symbol)
Entrez gene summary	Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	43169008 - 43172805
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160202 (version 83.38)
Entrez gene	1409
UniProt	P02489 (UniProt - Evidence at protein level)
neXtProt	NX_P02489
Antibodypedia	CRYAA antibodies

PROTEIN BROWSER

CRYAA-001	CRYAA-003	CRYAA-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYAA-001 ENSP00000291554 ENST00000291554	P02489 [Direct mapping] Alpha-crystallin A chain Alpha-crystallin A(1-172) Alpha-crystallin A(1-168) Alpha-crystallin A(1-162) Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007601 [visual perception] GO:0032387 [negative regulation of intracellular transport] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0050896 [response to stimulus] GO:0051082 [unfolded protein binding] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] Show all	173 aa 19.9 kDa	No	0
CRYAA-003 ENSP00000381201 ENST00000398133	E7EWH7 [Direct mapping] Alpha-crystallin A chain Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005212 [structural constituent of eye lens] Show all	153 aa 17 kDa	No	0
CRYAA-004 ENSP00000381200 ENST00000398132	E9PHE4 [Direct mapping] Alpha-crystallin A chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005212 [structural constituent of eye lens] Show all	136 aa 15.3 kDa	No	0