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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RRP1B
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    TISSUE

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    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Ribosomal RNA processing 1B

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA017893
HPA020324

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate nuclear or nucleolar and cytoplasmic immunoreactivity. Many cases of lymphomas, melanomas, colo-rectal and stomach cancers showed strong nuclear staining. A few cases of lung and hepatocellular carcinomas were weakly stained or negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed moderate nuclear staining. Several cases of renal, testicular, prostate and lung cancers were weakly stained.

GENE INFORMATION

Gene name

RRP1B (HGNC Symbol)

Synonyms

KIAA0179, Nnp1, PPP1R136, RRP1

Description

Ribosomal RNA processing 1B (HGNC Symbol)

Entrez gene summary

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

43659548 - 43696079

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160208 (version 83.38)

Entrez gene

23076

UniProt

Q14684 (UniProt - Evidence at protein level)

neXtProt

NX_Q14684

Antibodypedia

RRP1B antibodies

PROTEIN BROWSER

RRP1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RRP1B-001
ENSP00000339145
ENST00000340648
Q14684 [Direct mapping]
Ribosomal RNA processing protein 1 homolog B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000791 [euchromatin]
GO:0000792 [heterochromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0010923 [negative regulation of phosphatase activity]
GO:0030688 [preribosome, small subunit precursor]
GO:0044822 [poly(A) RNA binding]
Show all
758 aa
84.4 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.