We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of malignancies showed weak to moderate cytoplasmic staining. Malignant gliomas were generally negative.
GENE INFORMATION
Gene name
GAB3
Synonyms
Description
GRB2-associated binding protein 3 (HGNC Symbol)
Entrez gene summary
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]