Expression of C21orf33 in cancer - Summary

CANCER ATLAS

Gene description

Chromosome 21 open reading frame 33

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018517

GENE INFORMATION
Gene name	C21orf33 (HGNC Symbol)
Synonyms	D21S2048E, ES1, GT335, HES1, KNP-I, KNP-Ia, KNPH, KNPI
Description	Chromosome 21 open reading frame 33 (HGNC Symbol)
Entrez gene summary	This gene encodes a potential mitochondrial protein that is a member of the DJ-1/PfpI gene family. This protein is overexpressed in fetal Down syndrome brain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	44133605 - 44145723
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160221 (version 83.38)
Entrez gene	8209
UniProt	P30042 (UniProt - Evidence at protein level)
neXtProt	NX_P30042
Antibodypedia	C21orf33 antibodies

PROTEIN BROWSER

C21orf33-001	C21orf33-002	C21orf33-004	C21orf33-006	C21orf33-010	C21orf33-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C21orf33-001 ENSP00000291577 ENST00000291577	P30042 [Direct mapping] ES1 protein homolog, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	268 aa 28.2 kDa	Yes	0
C21orf33-002 ENSP00000396655 ENST00000427803	F2Z2Q0 [Direct mapping] ES1 protein homolog, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	217 aa 22.8 kDa	Yes	0
C21orf33-004 ENSP00000374340 ENST00000389690	H7BYH1 [Direct mapping] ES1 protein homolog, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		224 aa 23.9 kDa	No	0
C21orf33-006 ENSP00000400044 ENST00000449622	H7C1F6 [Direct mapping] ES1 protein homolog, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	257 aa 27.3 kDa	No	0
C21orf33-010 ENSP00000405713 ENST00000419699	H7C2G3 [Direct mapping] ES1 protein homolog, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	191 aa 20.2 kDa	No	0
C21orf33-011 ENSP00000344901 ENST00000348499	P30042 [Direct mapping] ES1 protein homolog, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	237 aa 24.8 kDa	Yes	0