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MCM3AP

GENERAL INFORMATION

Gene name

 MCM3AP

Gene description

 Minichromosome maintenance complex component 3 associated protein

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021527
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MCM3AP (HGNC Symbol)

Synonyms

 GANP, KIAA0572, Map80, SAC3

Description

 Minichromosome maintenance complex component 3 associated protein (HGNC Symbol)

Entrez gene summary

 The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 46235126 - 46286297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160294 (version 83.38)

Entrez gene

 8888

UniProt

 O60318 (UniProt - Evidence at protein level)

neXtProt

 NX_O60318

Antibodypedia

 MCM3AP antibodies

PROTEIN BROWSER
MCM3AP-001
MCM3AP-007
MCM3AP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCM3AP-001
ENSP00000380820
ENST00000397708
O60318 [Direct mapping]
Germinal-center associated nuclear protein
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006606 [protein import into nucleus]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031965 [nuclear membrane]
GO:0051028 [mRNA transport]
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 1980 aa
218.4 kDa 		No 0
MCM3AP-007
ENSP00000408934
ENST00000426537
A0A0A0MSZ7 [Direct mapping]
Germinal-center-associated nuclear protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
9.6 kDa 		No 0
MCM3AP-201
ENSP00000291688
ENST00000291688
O60318 [Direct mapping]
Germinal-center associated nuclear protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006606 [protein import into nucleus]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0031965 [nuclear membrane]
GO:0051028 [mRNA transport]
Show all
 1980 aa
218.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.