Tissue expression of DIP2A - Summary - The Human Protein Atlas

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DIP2A

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DIP2A
Gene description	Disco-interacting protein 2 homolog A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in smooth muscle.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA052516
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DIP2A (HGNC Symbol)
Synonyms	C21orf106, Dip2, KIAA0184
Description	Disco-interacting protein 2 homolog A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	46458899 - 46569852
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160305 (version 83.38)
Entrez gene	23181
UniProt	Q14689 (UniProt - Evidence at protein level)
neXtProt	NX_Q14689
Antibodypedia	DIP2A antibodies

PROTEIN BROWSER

DIP2A-001	DIP2A-002	DIP2A-003	DIP2A-004	DIP2A-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIP2A-001 ENSP00000383133 ENST00000400274	Q14689 [Direct mapping] Disco-interacting protein 2 homolog A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0042981 [regulation of apoptotic process] Show all	1567 aa 169.9 kDa	No	2
DIP2A-002 ENSP00000393434 ENST00000457905	Q14689 [Direct mapping] Disco-interacting protein 2 homolog A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0042981 [regulation of apoptotic process] Show all	889 aa 96 kDa	No	0
DIP2A-003 ENSP00000415089 ENST00000435722	Q14689 [Direct mapping] Disco-interacting protein 2 homolog A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0042981 [regulation of apoptotic process] Show all	841 aa 90.6 kDa	No	0
DIP2A-004 ENSP00000430249 ENST00000466639	Q14689 [Direct mapping] Disco-interacting protein 2 homolog A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0042981 [regulation of apoptotic process] Show all	798 aa 86 kDa	No	0
DIP2A-012 ENSP00000392066 ENST00000417564	Q14689 [Direct mapping] Disco-interacting protein 2 homolog A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007275 [multicellular organismal development] GO:0008134 [transcription factor binding] GO:0008152 [metabolic process] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0042981 [regulation of apoptotic process] Show all	1571 aa 170.4 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.