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ST6GALNAC6

CANCER ATLAS

Gene description

 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Protein class

 Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018890

GENE INFORMATION

Gene name

 ST6GALNAC6 (HGNC Symbol)

Synonyms

 SIAT7F, ST6GALNACVI

Description

 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (HGNC Symbol)

Entrez gene summary

 ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 127885321 - 127905408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160408 (version 83.38)

Entrez gene

 30815

UniProt

 Q969X2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969X2

Antibodypedia

 ST6GALNAC6 antibodies

PROTEIN BROWSER
ST6GALNAC6-006
ST6GALNAC6-007
ST6GALNAC6-008
ST6GALNAC6-010
ST6GALNAC6-011
ST6GALNAC6-201
ST6GALNAC6-202
ST6GALNAC6-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ST6GALNAC6-006
ENSP00000362235
ENST00000373142
Q969X2 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0001665 [alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006677 [glycosylceramide metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0009988 [cell-cell recognition]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 374 aa
40.8 kDa 		No 1
ST6GALNAC6-007
ENSP00000362239
ENST00000373146
Q969X2 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0001665 [alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006677 [glycosylceramide metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0009988 [cell-cell recognition]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 333 aa
38.1 kDa 		No 1
ST6GALNAC6-008
ENSP00000362237
ENST00000373144
Q969X2 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
A0A024R8C6 [Target identity:100%; Query identity:100%]
ST6 (Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, isoform CRA_b
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0001665 [alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006677 [glycosylceramide metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0009988 [cell-cell recognition]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 299 aa
34.3 kDa 		Yes 0
ST6GALNAC6-010
ENSP00000362234
ENST00000373141
Q969X2 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
A0A024R8C6 [Target identity:100%; Query identity:100%]
ST6 (Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, isoform CRA_b
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0001665 [alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006677 [glycosylceramide metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0009988 [cell-cell recognition]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 299 aa
34.3 kDa 		Yes 0
ST6GALNAC6-011
ENSP00000405326
ENST00000447681
X6RH99 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006486 [protein glycosylation]
GO:0008373 [sialyltransferase activity]
GO:0016021 [integral component of membrane]
GO:0097503 [sialylation]
Show all
 200 aa
22.5 kDa 		Yes 0
ST6GALNAC6-201
ENSP00000291839
ENST00000291839
Q969X2 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0001665 [alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006677 [glycosylceramide metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0009988 [cell-cell recognition]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 333 aa
38.1 kDa 		No 1
ST6GALNAC6-202
ENSP00000438109
ENST00000542456
F6SGE3 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.7 kDa 		Yes 0
ST6GALNAC6-203
ENSP00000477575
ENST00000622357
Q969X2 [Direct mapping]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
A0A024R8C6 [Target identity:100%; Query identity:100%]
ST6 (Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, isoform CRA_b
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001574 [ganglioside biosynthetic process]
GO:0001665 [alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006677 [glycosylceramide metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008373 [sialyltransferase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0009988 [cell-cell recognition]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 299 aa
34.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.