Cell atlas - PCSK7 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PCSK7
Gene description	Proprotein convertase subtilisin/kexin type 7
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus, nucleoli & nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (uncertain), Nuclear membrane (uncertain), Nucleoli (uncertain)
Mouse	Localized to the Nuclear membrane in mouse cells.

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA043181 , HPA052957
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus, nucleoli & nuclear membrane.

Main location

Nucleus (uncertain), Nuclear membrane (uncertain), Nucleoli (uncertain)


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Antibody	Cell line	Location
HPA043181	A-431	Nucleoli
HPA043181	U-2 OS	Nucleoli
HPA043181	U-251 MG	Nucleoli
HPA052957	A-431	Nucleoplasm
HPA052957	A-431	Nuclear membrane
HPA052957	U-2 OS	Nucleus
HPA052957	U-2 OS	Nuclear membrane
HPA052957	U-251 MG	Nucleoplasm
HPA052957	U-251 MG	Nuclear membrane

MOUSE CELLS

Main location

Nuclear membrane

Additional location

Nucleoplasm

Mouse gene

ENSMUSG00000035382 (version 83)


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Thumbnail	Antibody	Cell line	Location
	HPA052957	NIH 3T3	Nucleoplasm
	HPA052957	NIH 3T3	Nuclear membrane

GENE INFORMATION
Gene name	PCSK7 (HGNC Symbol)
Synonyms	LPC, PC7, PC8, SPC7
Description	Proprotein convertase subtilisin/kexin type 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	117204337 - 117232525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160613 (version 83.38)
Entrez gene	9159
UniProt	Q16549 (UniProt - Evidence at protein level)
neXtProt	NX_Q16549
Antibodypedia	PCSK7 antibodies

PROTEIN BROWSER

PCSK7-001	PCSK7-004	PCSK7-005	PCSK7-006	PCSK7-007	PCSK7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCSK7-001 ENSP00000325917 ENST00000320934	Q16549 [Direct mapping] Proprotein convertase subtilisin/kexin type 7 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0016485 [protein processing] GO:0016486 [peptide hormone processing] GO:0030173 [integral component of Golgi membrane] Show all	785 aa 86.2 kDa	No	2
PCSK7-004 ENSP00000431181 ENST00000525027	E9PMC0 [Direct mapping] Proprotein convertase subtilisin/kexin type 7 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	305 aa 33 kDa	No	0
PCSK7-005 ENSP00000433252 ENST00000530269	E9PLM0 [Direct mapping] Proprotein convertase subtilisin/kexin type 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	92 aa 9.5 kDa	No	1
PCSK7-006 ENSP00000436459 ENST00000532301	E9PLM0 [Direct mapping] Proprotein convertase subtilisin/kexin type 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	92 aa 9.5 kDa	No	1
PCSK7-007 ENSP00000433841 ENST00000524507	E9PIW7 [Direct mapping] Proprotein convertase subtilisin/kexin type 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	113 aa 11.8 kDa	No	1
PCSK7-201 ENSP00000441944 ENST00000540028	Q6PK65 [Direct mapping] PCSK7 protein; Proprotein convertase subtilisin/kexin type 7 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	591 aa 64.4 kDa	No	0