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CHTOP

GENERAL INFORMATION

Gene name

 CHTOP

Gene description

 Chromatin target of PRMT1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA028647
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHTOP (HGNC Symbol)

Synonyms

 C1orf77, DKFZP547E1010, FOP, SRAG

Description

 Chromatin target of PRMT1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153633982 - 153646306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160679 (version 83.38)

Entrez gene

 26097

UniProt

 Q9Y3Y2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3Y2

Antibodypedia

 CHTOP antibodies

PROTEIN BROWSER
CHTOP-001
CHTOP-002
CHTOP-004
CHTOP-005
CHTOP-201
CHTOP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHTOP-001
ENSP00000357683
ENST00000368694
Q9Y3Y2 [Direct mapping]
Chromatin target of PRMT1 protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006406 [mRNA export from nucleus]
GO:0016607 [nuclear speck]
GO:0032781 [positive regulation of ATPase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0051096 [positive regulation of helicase activity]
Show all
 248 aa
26.4 kDa 		No 0
CHTOP-002
ENSP00000385228
ENST00000403433
Q9Y3Y2 [Direct mapping]
Chromatin target of PRMT1 protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006406 [mRNA export from nucleus]
GO:0016607 [nuclear speck]
GO:0032781 [positive regulation of ATPase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0051096 [positive regulation of helicase activity]
Show all
 202 aa
21.9 kDa 		No 0
CHTOP-004
ENSP00000357676
ENST00000368687
X6R700 [Direct mapping]
Chromatin target of PRMT1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 223 aa
23.7 kDa 		No 0
CHTOP-005
ENSP00000357675
ENST00000368686
Q5T7Y7 [Direct mapping]
Chromatin target of PRMT1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 101 aa
10.9 kDa 		No 0
CHTOP-201
ENSP00000357679
ENST00000368690
Q9Y3Y2 [Direct mapping]
Chromatin target of PRMT1 protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006406 [mRNA export from nucleus]
GO:0016607 [nuclear speck]
GO:0032781 [positive regulation of ATPase activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0051096 [positive regulation of helicase activity]
Show all
 249 aa
26.5 kDa 		No 0
CHTOP-202
ENSP00000484038
ENST00000614256
A0A087X1B7 [Direct mapping]
Chromatin target of PRMT1 protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.