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CXCR5

GENERAL INFORMATION

Gene name

 CXCR5

Gene description

 Chemokine (C-X-C motif) receptor 5

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen, tonsil)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Group enriched (tonsil, spleen, appendix, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of leukocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042432 , CAB026149
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, spleen, appendix, lymph node)

GENE INFORMATION

Gene name

 CXCR5 (HGNC Symbol)

Synonyms

 BLR1, CD185, MDR15

Description

 Chemokine (C-X-C motif) receptor 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118883766 - 118897799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160683 (version 83.38)

Entrez gene

 643

UniProt

 P32302 (UniProt - Evidence at protein level)

neXtProt

 NX_P32302

Antibodypedia

 CXCR5 antibodies

PROTEIN BROWSER
CXCR5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCR5-001
ENSP00000292174
ENST00000292174
P32302 [Direct mapping]
C-X-C chemokine receptor type 5
A0N0R2 [Target identity:100%; Query identity:100%]
Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5), isoform CRA_a; C-x-c chemokine receptor type 5
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0032467 [positive regulation of cytokinesis]
GO:0042113 [B cell activation]
GO:0048535 [lymph node development]
GO:0070098 [chemokine-mediated signaling pathway]
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 372 aa
42 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.