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ANO10

GENERAL INFORMATION

Gene name

 ANO10

Gene description

 Anoctamin 10

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, some tissues show membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA051569
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ANO10 (HGNC Symbol)

Synonyms

 FLJ10375, MGC47890, SCAR10, TMEM16K

Description

 Anoctamin 10 (HGNC Symbol)

Entrez gene summary

 The transmembrane protein encoded by this gene is a member of a family of calcium-activated chloride channels. Defects in this gene may be a cause of autosomal recessive spinocerebellar ataxia-10. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Chromosome

 3

Cytoband

Chromosome location (bp)

 43354859 - 43691594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160746 (version 83.38)

Entrez gene

 55129

UniProt

 Q9NW15 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NW15

Antibodypedia

 ANO10 antibodies

PROTEIN BROWSER
«
ANO10-001
ANO10-002
ANO10-003
ANO10-004
ANO10-005
ANO10-007
ANO10-008
ANO10-009
ANO10-010
ANO10-011
ANO10-012
ANO10-013
ANO10-014
ANO10-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANO10-001
ENSP00000292246
ENST00000292246
Q9NW15 [Direct mapping]
Anoctamin-10
A0A024R2S0 [Target identity:100%; Query identity:100%]
Anoctamin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 660 aa
76.3 kDa 		No 8
ANO10-002
ENSP00000327767
ENST00000350459
Q9NW15 [Direct mapping]
Anoctamin-10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 470 aa
53.8 kDa 		No 4
ANO10-003
ENSP00000379398
ENST00000396091
Q9NW15 [Direct mapping]
Anoctamin-10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 594 aa
68.7 kDa 		No 8
ANO10-004
ENSP00000396990
ENST00000414522
Q9NW15 [Direct mapping]
Anoctamin-10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 627 aa
72.1 kDa 		No 7
ANO10-005
ENSP00000394119
ENST00000451430
Q9NW15 [Direct mapping]
Anoctamin-10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 549 aa
63.5 kDa 		No 8
ANO10-007
ENSP00000412997
ENST00000448045
H7C3N6 [Direct mapping]
Anoctamin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 188 aa
20.7 kDa 		Yes 3
ANO10-008
ENSP00000406432
ENST00000427171
C9J670 [Direct mapping]
Anoctamin-10
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 192 aa
22 kDa 		No 0
ANO10-009
ENSP00000416266
ENST00000428472
C9JH90 [Direct mapping]
Anoctamin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 162 aa
19 kDa 		No 2
ANO10-010
ENSP00000402010
ENST00000444344
C9JPY2 [Direct mapping]
Anoctamin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 146 aa
16.8 kDa 		No 0
ANO10-011
ENSP00000402845
ENST00000456438
C9JQC9 [Direct mapping]
Anoctamin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 141 aa
16.2 kDa 		No 0
ANO10-012
ENSP00000399103
ENST00000413397
C9IYD3 [Direct mapping]
Anoctamin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
16.1 kDa 		No 0
ANO10-013
ENSP00000397360
ENST00000439141
C9JA49 [Direct mapping]
Anoctamin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 134 aa
15.4 kDa 		No 0
ANO10-014
ENSP00000406712
ENST00000428831
C9IZD0 [Direct mapping]
Anoctamin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 112 aa
12.8 kDa 		No 0
ANO10-015
ENSP00000404988
ENST00000436073
C9JJS5 [Direct mapping]
Anoctamin-10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 38 aa
4.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.