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PTH1R

GENERAL INFORMATION

Gene name

 PTH1R

Gene description

 Parathyroid hormone 1 receptor

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in selected tissues at variable levels, including subsets of cells in kidney.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA007978
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 PTH1R (HGNC Symbol)

Synonyms

 PTHR, PTHR1

Description

 Parathyroid hormone 1 receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46877746 - 46903799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160801 (version 83.38)

Entrez gene

 5745

UniProt

 Q03431 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03431

Antibodypedia

 PTH1R antibodies

PROTEIN BROWSER
PTH1R-001
PTH1R-002
PTH1R-003
PTH1R-004
PTH1R-008
PTH1R-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTH1R-001
ENSP00000321999
ENST00000313049
Q03431 [Direct mapping]
Parathyroid hormone/parathyroid hormone-related peptide receptor
A0A024R2Z8 [Target identity:100%; Query identity:100%]
Parathyroid hormone receptor 1, isoform CRA_a
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0002062 [chondrocyte differentiation]
GO:0002076 [osteoblast development]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004991 [parathyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007568 [aging]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017046 [peptide hormone binding]
GO:0030282 [bone mineralization]
GO:0031526 [brush border membrane]
GO:0043235 [receptor complex]
GO:0043621 [protein self-association]
GO:0045453 [bone resorption]
GO:0048469 [cell maturation]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 593 aa
66.4 kDa 		Yes 7
PTH1R-002
ENSP00000402723
ENST00000449590
Q03431 [Direct mapping]
Parathyroid hormone/parathyroid hormone-related peptide receptor
A0A024R2Z8 [Target identity:100%; Query identity:100%]
Parathyroid hormone receptor 1, isoform CRA_a
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004991 [parathyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017046 [peptide hormone binding]
GO:0043235 [receptor complex]
GO:0043621 [protein self-association]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 593 aa
66.4 kDa 		Yes 7
PTH1R-003
ENSP00000411424
ENST00000418619
Q03431 [Direct mapping]
Parathyroid hormone/parathyroid hormone-related peptide receptor
A0A024R2Z8 [Target identity:100%; Query identity:100%]
Parathyroid hormone receptor 1, isoform CRA_a
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004991 [parathyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017046 [peptide hormone binding]
GO:0043235 [receptor complex]
GO:0043621 [protein self-association]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 593 aa
66.4 kDa 		Yes 7
PTH1R-004
ENSP00000400977
ENST00000427125
E7EWE7 [Direct mapping]
Parathyroid hormone/parathyroid hormone-related peptide receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004991 [parathyroid hormone receptor activity]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 527 aa
59.5 kDa 		Yes 7
PTH1R-008
ENSP00000396176
ENST00000422115
H7C0Q3 [Direct mapping]
Parathyroid hormone/parathyroid hormone-related peptide receptor
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004991 [parathyroid hormone receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
Show all
 182 aa
20 kDa 		No 0
PTH1R-201
ENSP00000413774
ENST00000430002
Q03431 [Direct mapping]
Parathyroid hormone/parathyroid hormone-related peptide receptor
A0A024R2Z8 [Target identity:100%; Query identity:100%]
Parathyroid hormone receptor 1, isoform CRA_a
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004991 [parathyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017046 [peptide hormone binding]
GO:0043235 [receptor complex]
GO:0043621 [protein self-association]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 593 aa
66.4 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.