Fields »
ABOUT
HELP
BLOG
FGFR4

CANCER ATLAS

Gene description

 Fibroblast growth factor receptor 4

Protein class

 Cancer-related genes, CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA027273
HPA027369
HPA028251
CAB005196

GENE INFORMATION

Gene name

 FGFR4 (HGNC Symbol)

Synonyms

 CD334, JTK2

Description

 Fibroblast growth factor receptor 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 177086886 - 177098144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160867 (version 83.38)

Entrez gene

 2264

UniProt

 P22455 (UniProt - Evidence at protein level)

neXtProt

 NX_P22455

Antibodypedia

 FGFR4 antibodies

PROTEIN BROWSER
FGFR4-001
FGFR4-002
FGFR4-003
FGFR4-004
FGFR4-008
FGFR4-009
FGFR4-010
FGFR4-012
FGFR4-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGFR4-001
ENSP00000292408
ENST00000292408
P22455 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019216 [regulation of lipid metabolic process]
GO:0030133 [transport vesicle]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0055062 [phosphate ion homeostasis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 802 aa
88 kDa 		Yes 1
FGFR4-002
ENSP00000377254
ENST00000393637
P22455 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019216 [regulation of lipid metabolic process]
GO:0030133 [transport vesicle]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0055062 [phosphate ion homeostasis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 762 aa
83.5 kDa 		Yes 0
FGFR4-003
ENSP00000377259
ENST00000393648
J3KPQ0 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 734 aa
80.5 kDa 		Yes 0
FGFR4-004
ENSP00000424960
ENST00000502906
P22455 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005007 [fibroblast growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0017134 [fibroblast growth factor binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019216 [regulation of lipid metabolic process]
GO:0030133 [transport vesicle]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042593 [glucose homeostasis]
GO:0045087 [innate immune response]
GO:0045862 [positive regulation of proteolysis]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0055062 [phosphate ion homeostasis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:2000188 [regulation of cholesterol homeostasis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 802 aa
88 kDa 		Yes 1
FGFR4-008
ENSP00000422889
ENST00000513166
D6R9V0 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 108 aa
11.8 kDa 		Yes 0
FGFR4-009
ENSP00000427222
ENST00000510911
D6RJD4 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 87 aa
9.5 kDa 		Yes 0
FGFR4-010
ENSP00000424905
ENST00000503708
E7EWF4 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 201 aa
22.2 kDa 		Yes 0
FGFR4-012
ENSP00000426492
ENST00000514472
D6RG06 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 114 aa
12.4 kDa 		Yes 0
FGFR4-014
ENSP00000424670
ENST00000511076
H0Y9P2 [Direct mapping]
Fibroblast growth factor receptor 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 280 aa
30.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.