Expression of NACC1 in cancer - Summary

CANCER ATLAS

Gene description

Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA021238	HPA062245

GENE INFORMATION
Gene name	NACC1 (HGNC Symbol)
Synonyms	BEND8, BTBD14B, BTBD30, NAC-1, NAC1
Description	Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	13118103 - 13141141
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160877 (version 83.38)
Entrez gene	112939
UniProt	Q96RE7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RE7
Antibodypedia	NACC1 antibodies

PROTEIN BROWSER

NACC1-001	NACC1-002	NACC1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NACC1-001 ENSP00000292431 ENST00000292431	Q96RE7 [Direct mapping] Nucleus accumbens-associated protein 1 A0A024R7E0 [Target identity:100%; Query identity:100%] BTB (POZ) domain containing 14B, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008284 [positive regulation of cell proliferation] GO:0016604 [nuclear body] GO:0030054 [cell junction] GO:0043231 [intracellular membrane-bounded organelle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051260 [protein homooligomerization] Show all	527 aa 57.3 kDa	No	0
NACC1-002 ENSP00000466017 ENST00000585663	K7ELC5 [Direct mapping] Nucleus accumbens-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005654 [nucleoplasm] GO:0030054 [cell junction] Show all	94 aa 10.5 kDa	No	0
NACC1-003 ENSP00000467120 ENST00000586171	K7ENW4 [Direct mapping] Nucleus accumbens-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] Show all	166 aa 18.2 kDa	No	0