Fields »
ABOUT
HELP
BLOG
RPL8

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 RPL8

Gene description

 Ribosomal protein L8

Protein class

 Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli, cytosol & endoplasmic reticulum.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (validated), Endoplasmic reticulum (validated), Cytosol (validated)

Mouse

 Localized to the Endoplasmic reticulum, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA050165
SHOW MORE

ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli, cytosol & endoplasmic reticulum.

Main location

 Nucleoli (validated), Endoplasmic reticulum (validated), Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050165 MCF7 Nucleoli
Endoplasmic reticulum
Cytosol
HPA050165 U-2 OS Nucleoli
Endoplasmic reticulum
Cytosol
HPA050165 U-251 MG Nucleoli
Endoplasmic reticulum
Cytosol

MOUSE CELLS

Main location

 Endoplasmic reticulum, Cytosol

Mouse gene

 ENSMUSG00000003970 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA050165 NIH 3T3 Endoplasmic reticulum
Cytosol

GENE INFORMATION

Gene name

 RPL8 (HGNC Symbol)

Synonyms

 L8

Description

 Ribosomal protein L8 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 144789765 - 144792587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161016 (version 83.38)

Entrez gene

 6132

UniProt

 P62917 (UniProt - Evidence at protein level)

neXtProt

 NX_P62917

Antibodypedia

 RPL8 antibodies

PROTEIN BROWSER
RPL8-001
RPL8-002
RPL8-010
RPL8-013
RPL8-014
RPL8-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPL8-001
ENSP00000262584
ENST00000262584
P62917 [Direct mapping]
60S ribosomal protein L8
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019843 [rRNA binding]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 257 aa
28 kDa 		No 0
RPL8-002
ENSP00000378378
ENST00000394920
P62917 [Direct mapping]
60S ribosomal protein L8
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019843 [rRNA binding]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 257 aa
28 kDa 		No 0
RPL8-010
ENSP00000433464
ENST00000528957
P62917 [Direct mapping]
60S ribosomal protein L8
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002181 [cytoplasmic translation]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019843 [rRNA binding]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 257 aa
28 kDa 		No 0
RPL8-013
ENSP00000436460
ENST00000527914
E9PP36 [Direct mapping]
60S ribosomal protein L8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 148 aa
16.2 kDa 		No 0
RPL8-014
ENSP00000434535
ENST00000532702
E9PKZ0 [Direct mapping]
60S ribosomal protein L8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 205 aa
22.4 kDa 		No 0
RPL8-016
ENSP00000435313
ENST00000533397
E9PKU4 [Direct mapping]
60S ribosomal protein L8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 235 aa
25.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.