Expression of PGLYRP2 in cancer - Summary

CANCER ATLAS

Gene description

Peptidoglycan recognition protein 2

Protein class

Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043568	HPA046311	CAB033468

GENE INFORMATION
Gene name	PGLYRP2 (HGNC Symbol)
Synonyms	PGLYRPL, PGRP-L, PGRPL, tagL, tagL-alpha, tagl-beta, TAGL-like
Description	Peptidoglycan recognition protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	15468645 - 15498956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161031 (version 83.38)
Entrez gene	114770
UniProt	Q96PD5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PD5
Antibodypedia	PGLYRP2 antibodies

PROTEIN BROWSER

PGLYRP2-001	PGLYRP2-002	PGLYRP2-003	PGLYRP2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGLYRP2-001 ENSP00000345968 ENST00000340880	Q96PD5 [Direct mapping] N-acetylmuramoyl-L-alanine amidase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001519 [peptide amidation] GO:0002221 [pattern recognition receptor signaling pathway] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity] GO:0009253 [peptidoglycan catabolic process] GO:0016019 [peptidoglycan receptor activity] GO:0016020 [membrane] GO:0016045 [detection of bacterium] GO:0032689 [negative regulation of interferon-gamma production] GO:0032827 [negative regulation of natural killer cell differentiation involved in immune response] GO:0042834 [peptidoglycan binding] GO:0044117 [growth of symbiont in host] GO:0045087 [innate immune response] GO:0050727 [regulation of inflammatory response] GO:0050830 [defense response to Gram-positive bacterium] GO:0070062 [extracellular exosome] Show all	576 aa 62.2 kDa	Yes	0
PGLYRP2-002 ENSP00000292609 ENST00000292609	Q96PD5 [Direct mapping] N-acetylmuramoyl-L-alanine amidase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001519 [peptide amidation] GO:0002221 [pattern recognition receptor signaling pathway] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity] GO:0009253 [peptidoglycan catabolic process] GO:0016019 [peptidoglycan receptor activity] GO:0016020 [membrane] GO:0016045 [detection of bacterium] GO:0042834 [peptidoglycan binding] GO:0045087 [innate immune response] GO:0050830 [defense response to Gram-positive bacterium] GO:0070062 [extracellular exosome] Show all	634 aa 68 kDa	Yes	0
PGLYRP2-003 ENSP00000472856 ENST00000601792	M0R2W8 [Direct mapping] N-acetylmuramoyl-L-alanine amidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity] GO:0009253 [peptidoglycan catabolic process] Show all	181 aa 19.5 kDa	No	1
PGLYRP2-004 ENSP00000470112 ENST00000594637	M0QYW3 [Direct mapping] N-acetylmuramoyl-L-alanine amidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity] GO:0009253 [peptidoglycan catabolic process] Show all	105 aa 11.4 kDa	Yes	0