Tissue expression of FBXL13 - Summary - The Human Protein Atlas

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FBXL13

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FBXL13
Gene description	F-box and leucine-rich repeat protein 13
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (testis, fallopian tube)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA057232
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (testis, fallopian tube)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	FBXL13 (HGNC Symbol)
Synonyms	DRC6, Fbl13, MGC21636
Description	F-box and leucine-rich repeat protein 13 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	102813230 - 103074843
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161040 (version 83.38)
Entrez gene	222235
UniProt	Q8NEE6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEE6
Antibodypedia	FBXL13 antibodies

PROTEIN BROWSER

FBXL13-001	FBXL13-003	FBXL13-005	FBXL13-006	FBXL13-007	FBXL13-008	FBXL13-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL13-001 ENSP00000321927 ENST00000313221	Q8NEE6 [Direct mapping] F-box/LRR-repeat protein 13 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	735 aa 83.9 kDa	No	0
FBXL13-003 ENSP00000368607 ENST00000379305	Q8NEE6 [Direct mapping] F-box/LRR-repeat protein 13 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	707 aa 80.7 kDa	No	0
FBXL13-005 ENSP00000391550 ENST00000455112	Q8NEE6 [Direct mapping] F-box/LRR-repeat protein 13 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	690 aa 79.1 kDa	No	0
FBXL13-006 ENSP00000388608 ENST00000436908	Q8NEE6 [Direct mapping] F-box/LRR-repeat protein 13 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	735 aa 83.9 kDa	No	0
FBXL13-007 ENSP00000409716 ENST00000456695	Q8NEE6 [Direct mapping] F-box/LRR-repeat protein 13 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	453 aa 52.7 kDa	No	0
FBXL13-008 ENSP00000390126 ENST00000440067	C9JI88 [Direct mapping] F-box/LRR-repeat protein 13 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	210 aa 25.1 kDa	No	0
FBXL13-201 ENSP00000368610 ENST00000379308	A0A0A0MRW5 [Direct mapping] F-box/LRR-repeat protein 13 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] Show all	683 aa 78.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.