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PSMC2

CANCER ATLAS

Gene description

 Proteasome 26S subunit, ATPase 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019238

GENE INFORMATION

Gene name

 PSMC2 (HGNC Symbol)

Synonyms

 MSS1, Nbla10058, S7

Description

 Proteasome 26S subunit, ATPase 2 (HGNC Symbol)

Entrez gene summary

 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 103344254 - 103369395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161057 (version 83.38)

Entrez gene

 5701

UniProt

 P35998 (UniProt - Evidence at protein level)

neXtProt

 NX_P35998

Antibodypedia

 PSMC2 antibodies

PROTEIN BROWSER
PSMC2-001
PSMC2-002
PSMC2-003
PSMC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSMC2-001
ENSP00000391211
ENST00000435765
P35998 [Direct mapping]
26S protease regulatory subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0001649 [osteoblast differentiation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016887 [ATPase activity]
GO:0017025 [TBP-class protein binding]
GO:0022624 [proteasome accessory complex]
GO:0030163 [protein catabolic process]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031595 [nuclear proteasome complex]
GO:0031597 [cytosolic proteasome complex]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036402 [proteasome-activating ATPase activity]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 433 aa
48.6 kDa 		No 0
PSMC2-002
ENSP00000393027
ENST00000425206
C9JLS9 [Direct mapping]
26S protease regulatory subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0017025 [TBP-class protein binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031595 [nuclear proteasome complex]
GO:0031597 [cytosolic proteasome complex]
GO:0036402 [proteasome-activating ATPase activity]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 130 aa
14.6 kDa 		No 0
PSMC2-003
ENSP00000401724
ENST00000457587
C9JLS9 [Direct mapping]
26S protease regulatory subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0017025 [TBP-class protein binding]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031595 [nuclear proteasome complex]
GO:0031597 [cytosolic proteasome complex]
GO:0036402 [proteasome-activating ATPase activity]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 130 aa
14.6 kDa 		No 0
PSMC2-201
ENSP00000292644
ENST00000292644
P35998 [Direct mapping]
26S protease regulatory subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0001649 [osteoblast differentiation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016887 [ATPase activity]
GO:0017025 [TBP-class protein binding]
GO:0022624 [proteasome accessory complex]
GO:0030163 [protein catabolic process]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031595 [nuclear proteasome complex]
GO:0031597 [cytosolic proteasome complex]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036402 [proteasome-activating ATPase activity]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
Show all
 433 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.