Tissue expression of DMKN - Summary - The Human Protein Atlas

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DMKN

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DMKN
Gene description	Dermokine
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	27
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skin)
GTEx:	Tissue enriched (skin)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Expression in squamous epithelium.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA029406
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DMKN (HGNC Symbol)
Synonyms	ZD52F10
Description	Dermokine (HGNC Symbol)
Entrez gene summary	This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35497220 - 35513658
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161249 (version 83.38)
Entrez gene	93099
UniProt	Q6E0U4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6E0U4
Antibodypedia	DMKN antibodies

PROTEIN BROWSER

DMKN-001	DMKN-002	DMKN-003	DMKN-004	DMKN-005	DMKN-006	DMKN-007	DMKN-008	DMKN-011	DMKN-021	DMKN-023	DMKN-027	DMKN-028	DMKN-029	DMKN-033	DMKN-034	DMKN-037	DMKN-038	DMKN-041	DMKN-043	DMKN-044	DMKN-048	DMKN-067	DMKN-068	DMKN-071	DMKN-074	DMKN-076

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMKN-001 ENSP00000342012 ENST00000339686	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0070062 [extracellular exosome] GO:1903575 [cornified envelope assembly] Show all	476 aa 47.1 kDa	Yes	0
DMKN-002 ENSP00000391036 ENST00000419602	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	465 aa 46.9 kDa	Yes	0
DMKN-003 ENSP00000405503 ENST00000429837	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	449 aa 45.1 kDa	Yes	0
DMKN-004 ENSP00000394908 ENST00000447113	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	436 aa 41.9 kDa	Yes	0
DMKN-005 ENSP00000414743 ENST00000418261	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	386 aa 37 kDa	Yes	0
DMKN-006 ENSP00000388404 ENST00000424570	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	398 aa 38.3 kDa	Yes	0
DMKN-007 ENSP00000409513 ENST00000451297	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	369 aa 35.3 kDa	Yes	0
DMKN-008 ENSP00000392222 ENST00000414866	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	189 aa 20.4 kDa	No	0
DMKN-011 ENSP00000474098 ENST00000461300	A3EZ84 [Direct mapping] Dermokine; Dermokine epsilon; Dermokine epsilon-1; Dermokine epsilon-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 4.1 kDa	No	0
DMKN-021 ENSP00000388378 ENST00000434389	H7BZ95 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		201 aa 21.9 kDa	No	0
DMKN-023 ENSP00000386225 ENST00000408915	Q6E0U4 [Direct mapping] Dermokine Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	90 aa 9.7 kDa	Yes	0
DMKN-027 ENSP00000473191 ENST00000488892	M0R3F8 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 8.6 kDa	No	0
DMKN-028 ENSP00000376042 ENST00000392206	E9PAQ7 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.3 kDa	No	0
DMKN-029 ENSP00000406864 ENST00000443640	C9IYI1 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		253 aa 26.8 kDa	No	0
DMKN-033 ENSP00000474123 ENST00000474928	A3EZ84 [Direct mapping] Dermokine; Dermokine epsilon; Dermokine epsilon-1; Dermokine epsilon-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 4.1 kDa	No	0
DMKN-034 ENSP00000472349 ENST00000480502	M0R265 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] Show all	184 aa 19.5 kDa	No	0
DMKN-037 ENSP00000471112 ENST00000467637	M0R0A5 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		201 aa 21.7 kDa	No	0
DMKN-038 ENSP00000397005 ENST00000450261	C9J3V3 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 11.7 kDa	No	0
DMKN-041 ENSP00000412075 ENST00000436012	C9J186 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.7 kDa	No	0
DMKN-043 ENSP00000384509 ENST00000402589	C9JCN1 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 21.8 kDa	No	0
DMKN-044 ENSP00000403957 ENST00000458071	E7EMS7 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 13.3 kDa	No	0
DMKN-048 ENSP00000474419 ENST00000492341	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	123 aa 14.1 kDa	No	0
DMKN-067 ENSP00000471487 ENST00000601650	M0R0W2 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 11.5 kDa	Yes	0
DMKN-068 ENSP00000471968 ENST00000593342	M0R1M0 [Direct mapping] Dermokine Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.1 kDa	Yes	0
DMKN-071 ENSP00000473296 ENST00000602679	R4GMQ0 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 11.2 kDa	No	0
DMKN-074 ENSP00000473341 ENST00000472252	Q6E0U4 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0070062 [extracellular exosome] Show all	123 aa 14.1 kDa	No	0
DMKN-076 ENSP00000473526 ENST00000602781	C9JCN1 [Direct mapping] Dermokine Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 21.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.