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This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
