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IKZF3

GENERAL INFORMATION

Gene name

 IKZF3

Gene description

 IKAROS family zinc finger 3 (Aiolos)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil, spleen)
GTEx:Tissue enhanced (small intestine, spleen)
FANTOM5:Group enriched (tonsil, appendix, spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in subsets of immune cells in several tissues, including lymphoid organs.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA024377
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, appendix, spleen, lymph node)

GENE INFORMATION

Gene name

 IKZF3 (HGNC Symbol)

Synonyms

 Aiolos, ZNFN1A3

Description

 IKAROS family zinc finger 3 (Aiolos) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Chromosome

 17

Cytoband

Chromosome location (bp)

 39757715 - 39864188

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161405 (version 83.38)

Entrez gene

 22806

UniProt

 Q9UKT9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKT9

Antibodypedia

 IKZF3 antibodies

PROTEIN BROWSER
«
IKZF3-001
IKZF3-002
IKZF3-003
IKZF3-004
IKZF3-005
IKZF3-006
IKZF3-009
IKZF3-010
IKZF3-011
IKZF3-012
IKZF3-013
IKZF3-014
IKZF3-015
IKZF3-016
IKZF3-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IKZF3-001
ENSP00000344544
ENST00000346872
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 509 aa
58 kDa 		No 0
IKZF3-002
ENSP00000403776
ENST00000439167
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 436 aa
49.8 kDa 		No 0
IKZF3-003
ENSP00000345622
ENST00000351680
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 470 aa
53.4 kDa 		No 0
IKZF3-004
ENSP00000341977
ENST00000346243
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 431 aa
49.1 kDa 		No 0
IKZF3-005
ENSP00000344471
ENST00000350532
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 470 aa
53.7 kDa 		No 0
IKZF3-006
ENSP00000420463
ENST00000467757
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 453 aa
51.6 kDa 		No 0
IKZF3-009
ENSP00000367180
ENST00000377945
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 375 aa
42.7 kDa 		No 0
IKZF3-010
ENSP00000377741
ENST00000394189
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 327 aa
36.9 kDa 		No 0
IKZF3-011
ENSP00000367179
ENST00000377944
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 366 aa
41.6 kDa 		No 0
IKZF3-012
ENSP00000367194
ENST00000377958
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 422 aa
48 kDa 		No 0
IKZF3-013
ENSP00000438972
ENST00000535189
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 475 aa
54.4 kDa 		No 0
IKZF3-014
ENSP00000367188
ENST00000377952
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 288 aa
32.7 kDa 		No 0
IKZF3-015
ENSP00000403027
ENST00000439016
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 414 aa
47 kDa 		No 0
IKZF3-016
ENSP00000462452
ENST00000583368
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 262 aa
30 kDa 		No 0
IKZF3-201
ENSP00000485515
ENST00000623724
Q9UKT9 [Direct mapping]
Zinc finger protein Aiolos
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007498 [mesoderm development]
GO:0030888 [regulation of B cell proliferation]
GO:0042113 [B cell activation]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045577 [regulation of B cell differentiation]
GO:0045619 [regulation of lymphocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
Show all
 262 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.