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FDXR

GENERAL INFORMATION

Gene name

 FDXR

Gene description

 Ferredoxin reductase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in selected tissues. Most abundant in adrenal gland, ovary, fallopian tube and male genitalia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA044393 , HPA053673 , CAB009818
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FDXR (HGNC Symbol)

Synonyms

 ADXR

Description

 Ferredoxin reductase (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 74862497 - 74873031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161513 (version 83.38)

Entrez gene

 2232

UniProt

 P22570 (UniProt - Evidence at protein level)

neXtProt

 NX_P22570

Antibodypedia

 FDXR antibodies

PROTEIN BROWSER
FDXR-001
FDXR-002
FDXR-003
FDXR-006
FDXR-008
FDXR-009
FDXR-011
FDXR-012
FDXR-013
FDXR-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FDXR-001
ENSP00000293195
ENST00000293195
A0A0C4DFN8 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 491 aa
53.8 kDa 		No 0
FDXR-002
ENSP00000416515
ENST00000442102
A0A0A0MT64 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
GO:0070995 [NADPH oxidation]
Show all
 534 aa
58.2 kDa 		No 0
FDXR-003
ENSP00000463940
ENST00000583917
J3QQX3 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 463 aa
50.6 kDa 		No 0
FDXR-006
ENSP00000462183
ENST00000582944
A0A0A0MTR6 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 483 aa
52.9 kDa 		No 0
FDXR-008
ENSP00000408595
ENST00000413947
A0A0A0MSZ4 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 522 aa
57.3 kDa 		No 0
FDXR-009
ENSP00000414172
ENST00000420580
P22570 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004324 [ferredoxin-NADP+ reductase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006694 [steroid biosynthetic process]
GO:0006700 [C21-steroid hormone biosynthetic process]
GO:0006744 [ubiquinone biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016125 [sterol metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 451 aa
49.4 kDa 		No 0
FDXR-011
ENSP00000445432
ENST00000544854
A0A0A0MTN9 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 439 aa
48 kDa 		No 0
FDXR-012
ENSP00000463308
ENST00000579893
J3QKZ8 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 164 aa
18 kDa 		No 0
FDXR-013
ENSP00000463934
ENST00000581219
J3QQW7 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 178 aa
19.5 kDa 		No 0
FDXR-018
ENSP00000462972
ENST00000581530
A0A0C4DGN7 [Direct mapping]
NADPH:adrenodoxin oxidoreductase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0015039 [NADPH-adrenodoxin reductase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 497 aa
54.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.