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Most malignancies displayed moderate cytoplasmic positivity. Liver and thyroid cancers as well as several cases of malignant lymphomas and colorectal cancers were strongly stained. A majority of malignant carcinoids, lung, skin and stomach cancers were weakly stained or negative.
Moderate to strong cytoplasmic immunoreactivity was displayed in liver carcinomas. Prostate, colorectal, gastric, lung and pancreatic cancers showed weak to moderate staining. Remaining malignant cells were weakly stained or negative.
Most cancer tissues showed weak to moderate cytoplasmic staining. Endometrial, cervical, pancreatic, liver, prostate and ovarian cancers displayed strong cytoplasmic positivity.
GENE INFORMATION
Gene name
ACOX1 (HGNC Symbol)
Synonyms
PALMCOX
Description
Acyl-CoA oxidase 1, palmitoyl (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Q15067 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 1
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Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q15067 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 1
Show all
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)