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ACOX1

CANCER ATLAS

Gene description

 Acyl-CoA oxidase 1, palmitoyl

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021192
HPA021195
HPA028759
CAB021094

GENE INFORMATION

Gene name

 ACOX1 (HGNC Symbol)

Synonyms

 PALMCOX

Description

 Acyl-CoA oxidase 1, palmitoyl (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75941507 - 75979363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161533 (version 83.38)

Entrez gene

 51

UniProt

 Q15067 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15067

Antibodypedia

 ACOX1 antibodies

PROTEIN BROWSER
ACOX1-001
ACOX1-002
ACOX1-005
ACOX1-009
ACOX1-012
ACOX1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOX1-001
ENSP00000293217
ENST00000293217
Q15067 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005782 [peroxisomal matrix]
GO:0005886 [plasma membrane]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006693 [prostaglandin metabolic process]
GO:0007283 [spermatogenesis]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016020 [membrane]
GO:0016401 [palmitoyl-CoA oxidase activity]
GO:0016559 [peroxisome fission]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0019395 [fatty acid oxidation]
GO:0030165 [PDZ domain binding]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047485 [protein N-terminus binding]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 660 aa
74.7 kDa 		No 0
ACOX1-002
ENSP00000301608
ENST00000301608
Q15067 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0003997 [acyl-CoA oxidase activity]
GO:0005102 [receptor binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005886 [plasma membrane]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0006693 [prostaglandin metabolic process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016020 [membrane]
GO:0016401 [palmitoyl-CoA oxidase activity]
GO:0016559 [peroxisome fission]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0019395 [fatty acid oxidation]
GO:0030165 [PDZ domain binding]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047485 [protein N-terminus binding]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
GO:2000189 [positive regulation of cholesterol homeostasis]
Show all
 660 aa
74.4 kDa 		No 0
ACOX1-005
ENSP00000461486
ENST00000576743
I3L4S5 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 108 aa
12.4 kDa 		No 0
ACOX1-009
ENSP00000466921
ENST00000587927
K7ENF1 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003997 [acyl-CoA oxidase activity]
GO:0005777 [peroxisome]
GO:0006635 [fatty acid beta-oxidation]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 132 aa
14.9 kDa 		No 0
ACOX1-012
ENSP00000466210
ENST00000588176
K7ELT1 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 157 aa
18.2 kDa 		No 0
ACOX1-014
ENSP00000468651
ENST00000588968
K7ESC7 [Direct mapping]
Peroxisomal acyl-coenzyme A oxidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003997 [acyl-CoA oxidase activity]
GO:0005777 [peroxisome]
GO:0006635 [fatty acid beta-oxidation]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 153 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.