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HCRT

GENERAL INFORMATION

Gene name

 HCRT

Gene description

 Hypocretin (orexin) neuropeptide precursor

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (hypothalamus)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. External RNA data suggests expression in hypothalamus. No internal RNA expression data available for correlation.

Reliability score

 Uncertain based on 1 antibody.
CAB004758
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hypothalamus)

GENE INFORMATION

Gene name

 HCRT (HGNC Symbol)

Synonyms

 OX, PPOX

Description

 Hypocretin (orexin) neuropeptide precursor (HGNC Symbol)

Entrez gene summary

 This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 42184060 - 42185452

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161610 (version 83.38)

Entrez gene

 3060

UniProt

 O43612 (UniProt - Evidence at protein level)

neXtProt

 NX_O43612

Antibodypedia

 HCRT antibodies

PROTEIN BROWSER
HCRT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCRT-001
ENSP00000293330
ENST00000293330
O43612 [Direct mapping]
Orexin Orexin-A Orexin-B
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005791 [rough endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007631 [feeding behavior]
GO:0008021 [synaptic vesicle]
GO:0008156 [negative regulation of DNA replication]
GO:0030054 [cell junction]
GO:0030141 [secretory granule]
GO:0031771 [type 1 hypocretin receptor binding]
GO:0031772 [type 2 hypocretin receptor binding]
GO:0042755 [eating behavior]
GO:0043267 [negative regulation of potassium ion transport]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051928 [positive regulation of calcium ion transport]
GO:0051970 [negative regulation of transmission of nerve impulse]
GO:0051971 [positive regulation of transmission of nerve impulse]
GO:0060079 [excitatory postsynaptic potential]
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 131 aa
13.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.