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SIGLEC11

GENERAL INFORMATION

Gene name

 SIGLEC11

Gene description

 Sialic acid binding Ig-like lectin 11

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (ovary, spleen)
GTEx:Tissue enhanced (ovary, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells in several tissues, including placental Hofbauer cells.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA060278
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (ovary, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, spleen)

GENE INFORMATION

Gene name

 SIGLEC11

Synonyms

Description

 Sialic acid binding Ig-like lectin 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49948985 - 49961172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161640 (version 83.38)

Entrez gene

 114132

UniProt

 Q96RL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RL6

Antibodypedia

 SIGLEC11 antibodies

PROTEIN BROWSER
SIGLEC11-001
SIGLEC11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIGLEC11-001
ENSP00000412361
ENST00000447370
Q96RL6 [Direct mapping]
Sialic acid-binding Ig-like lectin 11
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
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 698 aa
75.8 kDa 		Yes 1
SIGLEC11-002
ENSP00000398891
ENST00000426971
Q96RL6 [Direct mapping]
Sialic acid-binding Ig-like lectin 11
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007155 [cell adhesion]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
Show all
 602 aa
65.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.