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FMNL3

GENERAL INFORMATION

Gene name

 FMNL3

Gene description

 Formin-like 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA002552 , HPA023201
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FMNL3 (HGNC Symbol)

Synonyms

 DKFZp762B245, MGC45819, WBP3

Description

 Formin-like 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49636499 - 49708165

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161791 (version 83.38)

Entrez gene

 91010

UniProt

 Q8IVF7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IVF7

Antibodypedia

 FMNL3 antibodies

PROTEIN BROWSER
FMNL3-001
FMNL3-002
FMNL3-003
FMNL3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FMNL3-001
ENSP00000344311
ENST00000352151
Q8IVF7 [Direct mapping]
Formin-like protein 3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016043 [cellular component organization]
GO:0016477 [cell migration]
GO:0017048 [Rho GTPase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0032794 [GTPase activating protein binding]
Show all
 976 aa
111.3 kDa 		No 0
FMNL3-002
ENSP00000335655
ENST00000335154
Q8IVF7 [Direct mapping]
Formin-like protein 3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016043 [cellular component organization]
GO:0016477 [cell migration]
GO:0017048 [Rho GTPase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0032794 [GTPase activating protein binding]
Show all
 1027 aa
116.9 kDa 		No 0
FMNL3-003
ENSP00000447479
ENST00000550488
F8W1F5 [Direct mapping]
Formin-like protein 3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0016043 [cellular component organization]
GO:0017048 [Rho GTPase binding]
GO:0030036 [actin cytoskeleton organization]
Show all
 1027 aa
117.1 kDa 		No 0
FMNL3-006
ENSP00000448939
ENST00000550424
F8VYL1 [Direct mapping]
Formin-like protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
 55 aa
6.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.