Expression of ASGR2 in cancer - Summary

CANCER ATLAS

Gene description

Asialoglycoprotein receptor 2

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014899	HPA015998

GENE INFORMATION
Gene name	ASGR2 (HGNC Symbol)
Synonyms	CLEC4H2
Description	Asialoglycoprotein receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7101322 - 7115700
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161944 (version 83.38)
Entrez gene	433
UniProt	P07307 (UniProt - Evidence at protein level)
neXtProt	NX_P07307
Antibodypedia	ASGR2 antibodies

PROTEIN BROWSER

ASGR2-001	ASGR2-002	ASGR2-003	ASGR2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASGR2-001 ENSP00000254850 ENST00000254850	P07307 [Direct mapping] Asialoglycoprotein receptor 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004873 [asialoglycoprotein receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	287 aa 32.6 kDa	No	0
ASGR2-002 ENSP00000347140 ENST00000355035	P07307 [Direct mapping] Asialoglycoprotein receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004873 [asialoglycoprotein receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0009100 [glycoprotein metabolic process] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0030282 [bone mineralization] GO:0031647 [regulation of protein stability] GO:0055088 [lipid homeostasis] Show all	311 aa 35.1 kDa	No	1
ASGR2-003 ENSP00000405844 ENST00000446679	P07307 [Direct mapping] Asialoglycoprotein receptor 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004873 [asialoglycoprotein receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	292 aa 33 kDa	No	0
ASGR2-007 ENSP00000458835 ENST00000574868	I3L1H2 [Direct mapping] Asialoglycoprotein receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	135 aa 14.7 kDa	No	1