Cell atlas - FGF11 - The Human Protein Atlas

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FGF11

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	FGF11
Gene description	Fibroblast growth factor 11
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome.
RNA cell category	Cell line enhanced (HaCaT)
Protein evidence	Evidence at transcript level
Main location	Localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066605
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome.

Main location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066605	A-431	Centrosome
	HPA066605	HaCaT	Centrosome
	HPA066605	U-2 OS	Centrosome

GENE INFORMATION
Gene name	FGF11 (HGNC Symbol)
Synonyms	FHF3, FLJ16061, MGC102953, MGC45269
Description	Fibroblast growth factor 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7438273 - 7444937
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000161958 (version 83.38)
Entrez gene	2256
UniProt	Q92914 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92914
Antibodypedia	FGF11 antibodies

PROTEIN BROWSER

FGF11-001	FGF11-002	FGF11-004	FGF11-005	FGF11-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FGF11-001 ENSP00000293829 ENST00000293829	Q92914 [Direct mapping] Fibroblast growth factor 11 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0008083 [growth factor activity] Show all	225 aa 25 kDa	No	0
FGF11-002 ENSP00000459746 ENST00000575235	I3L4N4 [Direct mapping] Fibroblast growth factor Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005576 [extracellular region] GO:0008083 [growth factor activity] Show all	101 aa 11.4 kDa	No	0
FGF11-004 ENSP00000465134 ENST00000572907	I3L4N4 [Direct mapping] Fibroblast growth factor Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005576 [extracellular region] GO:0008083 [growth factor activity] Show all	101 aa 11.4 kDa	No	0
FGF11-005 ENSP00000460753 ENST00000575398	I3L4N4 [Direct mapping] Fibroblast growth factor Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005576 [extracellular region] GO:0008083 [growth factor activity] Show all	101 aa 11.4 kDa	No	0
FGF11-006 ENSP00000461397 ENST00000575082	I3L4N4 [Direct mapping] Fibroblast growth factor Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005576 [extracellular region] GO:0008083 [growth factor activity] Show all	101 aa 11.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.