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NXF1

CANCER ATLAS

Gene description

 Nuclear RNA export factor 1

Protein class

 Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA061593
CAB016327

GENE INFORMATION

Gene name

 NXF1 (HGNC Symbol)

Synonyms

 DKFZp667O0311, Mex67, TAP

Description

 Nuclear RNA export factor 1 (HGNC Symbol)

Entrez gene summary

 This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62792123 - 62806302

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162231 (version 83.38)

Entrez gene

 10482

UniProt

 Q9UBU9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBU9

Antibodypedia

 NXF1 antibodies

PROTEIN BROWSER
NXF1-001
NXF1-002
NXF1-003
NXF1-004
NXF1-006
NXF1-012
NXF1-013
NXF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NXF1-001
ENSP00000436679
ENST00000532297
Q9UBU9 [Direct mapping]
Nuclear RNA export factor 1
Show all
Transporters
   Primary Active Transporters
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000346 [transcription export complex]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006810 [transport]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
Show all
 619 aa
70.2 kDa 		No 0
NXF1-002
ENSP00000437296
ENST00000531474
E9PMV7 [Direct mapping]
Nuclear RNA export factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
7.3 kDa 		No 0
NXF1-003
ENSP00000435742
ENST00000530875
E9PIN3 [Direct mapping]
Nuclear RNA export factor 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
GO:0006810 [transport]
Show all
 603 aa
68.1 kDa 		No 0
NXF1-004
ENSP00000477375
ENST00000531131
B4E227 [Direct mapping]
Nuclear RNA export factor 1; cDNA FLJ61053, highly similar to Nuclear RNA export factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
Show all
 219 aa
24.7 kDa 		No 0
NXF1-006
ENSP00000453885
ENST00000531709
Q9UBU9 [Direct mapping]
Nuclear RNA export factor 1
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000346 [transcription export complex]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0044822 [poly(A) RNA binding]
Show all
 356 aa
40.5 kDa 		No 0
NXF1-012
ENSP00000431381
ENST00000533671
E9PLA7 [Direct mapping]
Nuclear RNA export factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006406 [mRNA export from nucleus]
Show all
 115 aa
13.2 kDa 		No 0
NXF1-013
ENSP00000434301
ENST00000527902
H0YDU0 [Direct mapping]
Nuclear RNA export factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006810 [transport]
GO:0051028 [mRNA transport]
Show all
 124 aa
13.5 kDa 		No 0
NXF1-201
ENSP00000294172
ENST00000294172
Q9UBU9 [Direct mapping]
Nuclear RNA export factor 1
Show all
Transporters
   Primary Active Transporters
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000346 [transcription export complex]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006406 [mRNA export from nucleus]
GO:0006810 [transport]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0016973 [poly(A)+ mRNA export from nucleus]
GO:0044822 [poly(A) RNA binding]
GO:0051028 [mRNA transport]
Show all
 619 aa
70.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.