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Cancer tissues showed weak to moderate cytoplasmic staining. Several cases of colorectal cancers along with few cases of prostate and endometrial cancers displayed strong positivity. Few cases of prostate cancers showed additional nuclear immunoreactivity.
GENE INFORMATION
Gene name
RPL29 (HGNC Symbol)
Synonyms
HIP, HUMRPL29, L29, RPL29P10
Description
Ribosomal protein L29 (HGNC Symbol)
Entrez gene summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]