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A majority of renal cancers showed moderate to strong cytoplasmic and membranous staining. Several hepatocellular carcinomas displayed weak to moderate cytoplasmic and nuclear positivity. Remaining cancer tissues were weakly stained or negative.
Most cancer cells showed weak to moderate cytoplasmic positivity with additional nuclear staining in several cases. Several endometrial cancer and hepatocellular carcinomas were strongly stained.
Low density lipoprotein receptor-related protein 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]