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Most tumour tissues showed moderate cytoplasmic positivity. Several cases of renal cancers and carcinoids as well as colorectal and endometrial cancers were strongly stained. A majority of lymphomas, prostate, ovarian, gastric and pancreatic cancers were negative.
Many cases of gliomas, melanomas, breast, colorectal, prostate, ovarian and thyroid cancers exhibited weak to moderate cytoplasmic positivity. Occasional colorectal cancers were strongly stained. Remaining tumour tissues were negative.
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]
