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Weak to moderate immunoreactivity was seen mainly in pancreatic, urothelial, testis, skin, ovarian and breast cancers as well as malignant glioma and lymphoma. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
PLPP3 (HGNC Symbol)
Synonyms
LPP3, PAP-2b, PPAP2B
Description
Phospholipid phosphatase 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]