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Many renal cell carcinomas, breast cancers along with few melanomas, endometrial, occasional lung, pancreatic and liver cancer tissues showed moderate cytoplasmic positivity. Other cancer tissues were weakly stained or in general negative.
GENE INFORMATION
Gene name
PRKAA2 (HGNC Symbol)
Synonyms
AMPK, AMPKa2, PRKAA
Description
Protein kinase, AMP-activated, alpha 2 catalytic subunit (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]