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RBBP4

CANCER ATLAS

Gene description

 Retinoblastoma binding protein 4

Protein class

 Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060724
CAB006264

GENE INFORMATION

Gene name

 RBBP4 (HGNC Symbol)

Synonyms

 lin-53, NURF55, RbAp48

Description

 Retinoblastoma binding protein 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 1

Cytoband

 p35.1

Chromosome location (bp)

 32651142 - 32686211

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162521 (version 83.38)

Entrez gene

 5928

UniProt

 Q09028 (UniProt - Evidence at protein level)

neXtProt

 NX_Q09028

Antibodypedia

 RBBP4 antibodies

PROTEIN BROWSER
RBBP4-001
RBBP4-002
RBBP4-003
RBBP4-004
RBBP4-007
RBBP4-008
RBBP4-010
RBBP4-011
RBBP4-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBBP4-001
ENSP00000362592
ENST00000373493
Q09028 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0016589 [NURF complex]
GO:0031492 [nucleosomal DNA binding]
GO:0031497 [chromatin assembly]
GO:0033186 [CAF-1 complex]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0051726 [regulation of cell cycle]
GO:0060416 [response to growth hormone]
Show all
 425 aa
47.7 kDa 		No 0
RBBP4-002
ENSP00000362584
ENST00000373485
Q09028 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0016589 [NURF complex]
GO:0031492 [nucleosomal DNA binding]
GO:0031497 [chromatin assembly]
GO:0033186 [CAF-1 complex]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0051726 [regulation of cell cycle]
Show all
 410 aa
46.2 kDa 		No 0
RBBP4-003
ENSP00000396057
ENST00000458695
Q09028 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0016589 [NURF complex]
GO:0031492 [nucleosomal DNA binding]
GO:0031497 [chromatin assembly]
GO:0033186 [CAF-1 complex]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0051726 [regulation of cell cycle]
Show all
 390 aa
43.5 kDa 		No 0
RBBP4-004
ENSP00000437210
ENST00000490500
E9PND5 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.7 kDa 		No 0
RBBP4-007
ENSP00000436986
ENST00000475321
H0YF10 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 207 aa
23.2 kDa 		No 0
RBBP4-008
ENSP00000433805
ENST00000463378
H0YDK2 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 262 aa
30.1 kDa 		No 0
RBBP4-010
ENSP00000436565
ENST00000482190
H0YEU5 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 167 aa
19 kDa 		No 0
RBBP4-011
ENSP00000398242
ENST00000414241
Q09028 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0016589 [NURF complex]
GO:0031492 [nucleosomal DNA binding]
GO:0031497 [chromatin assembly]
GO:0033186 [CAF-1 complex]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0051726 [regulation of cell cycle]
Show all
 424 aa
47.6 kDa 		No 0
RBBP4-013
ENSP00000389437
ENST00000445722
C9JPP3 [Direct mapping]
Histone-binding protein RBBP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
9.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.