Cell atlas - ALPL - The Human Protein Atlas

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ALPL

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ALPL
Gene description	Alkaline phosphatase, liver/bone/kidney
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Group enriched (SCLC-21H, LHCN-M2, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA008765 , CAB020829
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, LHCN-M2, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB020829	A-431	Cytosol
	CAB020829	U-2 OS	Cytosol
	CAB020829	U-251 MG	Cytosol
	HPA008765	A-431	Cytosol
	HPA008765	U-2 OS	Cytosol
	HPA008765	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ALPL (HGNC Symbol)
Synonyms	HOPS, TNSALP
Description	Alkaline phosphatase, liver/bone/kidney (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	21509372 - 21578412
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162551 (version 83.38)
Entrez gene	249
UniProt	P05186 (UniProt - Evidence at protein level)
neXtProt	NX_P05186
Antibodypedia	ALPL antibodies

PROTEIN BROWSER

ALPL-001	ALPL-002	ALPL-004	ALPL-006	ALPL-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALPL-001 ENSP00000363973 ENST00000374840	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme A0A024RAG0 [Target identity:100%; Query identity:100%] Alkaline phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0001958 [endochondral ossification] GO:0003006 [developmental process involved in reproduction] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0032496 [response to lipopolysaccharide] GO:0033280 [response to vitamin D] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0051384 [response to glucocorticoid] GO:0065010 [extracellular membrane-bounded organelle] GO:0070062 [extracellular exosome] GO:0071407 [cellular response to organic cyclic compound] GO:0071529 [cementum mineralization] Show all	524 aa 57.3 kDa	Yes	0
ALPL-002 ENSP00000363965 ENST00000374832	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme A0A024RAG0 [Target identity:100%; Query identity:100%] Alkaline phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0033280 [response to vitamin D] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	524 aa 57.3 kDa	Yes	0
ALPL-004 ENSP00000363963 ENST00000374830	B1ANL0 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	216 aa 23 kDa	No	0
ALPL-006 ENSP00000437674 ENST00000539907	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0033280 [response to vitamin D] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	447 aa 48.9 kDa	No	1
ALPL-007 ENSP00000442672 ENST00000540617	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0033280 [response to vitamin D] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	469 aa 51 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.