Expression of OMA1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

OMA1 zinc metallopeptidase

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA055120

GENE INFORMATION
Gene name	OMA1 (HGNC Symbol)
Synonyms	FLJ33782, MPRP-1, YKR087C, ZMPOMA1
Description	OMA1 zinc metallopeptidase (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband
Chromosome location (bp)	58415384 - 58546802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162600 (version 83.38)
Entrez gene	115209
UniProt	Q96E52 (UniProt - Evidence at protein level)
neXtProt	NX_Q96E52
Antibodypedia	OMA1 antibodies

PROTEIN BROWSER

OMA1-001	OMA1-002	OMA1-003	OMA1-005	OMA1-007	OMA1-008	OMA1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OMA1-001 ENSP00000360270 ENST00000371226	Q96E52 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002024 [diet induced thermogenesis] GO:0004222 [metalloendopeptidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006006 [glucose metabolic process] GO:0006508 [proteolysis] GO:0006515 [misfolded or incompletely synthesized protein catabolic process] GO:0006629 [lipid metabolic process] GO:0006950 [response to stress] GO:0007005 [mitochondrion organization] GO:0010637 [negative regulation of mitochondrial fusion] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0034982 [mitochondrial protein processing] GO:0042407 [cristae formation] GO:0046872 [metal ion binding] GO:0097009 [energy homeostasis] Show all	524 aa 60.1 kDa	No	3
OMA1-002 ENSP00000391941 ENST00000421528	H7BZX2 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	328 aa 37.7 kDa	No	2
OMA1-003 ENSP00000416495 ENST00000426139	X6RL62 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	253 aa 29.2 kDa	No	2
OMA1-005 ENSP00000409589 ENST00000419242	X6RIG5 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	255 aa 29.4 kDa	No	2
OMA1-007 ENSP00000392978 ENST00000453710	X6RD49 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		184 aa 21 kDa	No	0
OMA1-008 ENSP00000474081 ENST00000482274	S4R3A3 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		87 aa 9.9 kDa	No	0
OMA1-009 ENSP00000395053 ENST00000456980	X6RDQ1 [Direct mapping] Metalloendopeptidase OMA1, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	326 aa 37.4 kDa	No	2