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Most of the malignant cells displayed weak to moderate nuclear and occasional cytoplasmic positivity.
GENE INFORMATION
Gene name
USP1
Synonyms
Description
Ubiquitin specific peptidase 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006282 [regulation of DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0009411 [response to UV] GO:0016579 [protein deubiquitination] GO:0019985 [translesion synthesis] GO:0035520 [monoubiquitinated protein deubiquitination] GO:0036297 [interstrand cross-link repair] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006281 [DNA repair] GO:0006282 [regulation of DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0009411 [response to UV] GO:0016579 [protein deubiquitination] GO:0019985 [translesion synthesis] GO:0035520 [monoubiquitinated protein deubiquitination] GO:0036297 [interstrand cross-link repair] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process]
