Expression of FUBP1 in cancer - Summary

CANCER ATLAS

Gene description

Far upstream element (FUSE) binding protein 1

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006149

GENE INFORMATION
Gene name	FUBP1 (HGNC Symbol)
Synonyms	FBP, FUBP
Description	Far upstream element (FUSE) binding protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	77944055 - 77979110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162613 (version 83.38)
Entrez gene	8880
UniProt	Q96AE4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AE4
Antibodypedia	FUBP1 antibodies

PROTEIN BROWSER

FUBP1-002	FUBP1-003	FUBP1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUBP1-002 ENSP00000359804 ENST00000370768	Q96AE4 [Direct mapping] Far upstream element-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010628 [positive regulation of gene expression] GO:0044822 [poly(A) RNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	644 aa 67.6 kDa	No	0
FUBP1-003 ENSP00000359803 ENST00000370767	E9PEB5 [Direct mapping] Far upstream element-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] Show all	655 aa 68.9 kDa	No	0
FUBP1-004 ENSP00000402630 ENST00000421641	C9JSZ1 [Direct mapping] Far upstream element-binding protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] Show all	232 aa 24 kDa	No	0