Cell atlas - B3GALT2 - The Human Protein Atlas

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B3GALT2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	B3GALT2
Gene description	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Group enriched (WM-115, AF22, LHCN-M2, ASC TERT1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA078659
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (WM-115, AF22, LHCN-M2, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA078659	ASC TERT1	Plasma membrane

GENE INFORMATION
Gene name	B3GALT2 (HGNC Symbol)
Synonyms	beta3Gal-T2
Description	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q31.2
Chromosome location (bp)	193179045 - 193186654
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000162630 (version 83.38)
Entrez gene	8707
UniProt	O43825 (UniProt - Evidence at transcript level)
neXtProt	NX_O43825
Antibodypedia	B3GALT2 antibodies

PROTEIN BROWSER

B3GALT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GALT2-001 ENSP00000356404 ENST00000367434	O43825 [Direct mapping] Beta-1,3-galactosyltransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0008499 [UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	422 aa 49.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.