Tissue expression of BRINP3 - Summary - The Human Protein Atlas

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BRINP3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BRINP3
Gene description	Bone morphogenetic protein/retinoic acid inducible neural-specific 3
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, small intestine)
GTEx:	Tissue enhanced (hypothalamus, cerebral cortex)
FANTOM5:	Tissue enhanced (cerebellum, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA054693
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hypothalamus, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, small intestine)

GENE INFORMATION
Gene name	BRINP3 (HGNC Symbol)
Synonyms	DBCCR1L, DBCCR1L1, FAM5C
Description	Bone morphogenetic protein/retinoic acid inducible neural-specific 3 (HGNC Symbol)
Entrez gene summary	This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	1
Cytoband	q31.1
Chromosome location (bp)	190097662 - 190478404
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162670 (version 83.38)
Entrez gene	339479
UniProt	Q76B58 (UniProt - Evidence at protein level)
neXtProt	NX_Q76B58
Antibodypedia	BRINP3 antibodies

PROTEIN BROWSER

BRINP3-001	BRINP3-003	BRINP3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRINP3-001 ENSP00000356432 ENST00000367462	Q76B58 [Direct mapping] BMP/retinoic acid-inducible neural-specific protein 3 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0007050 [cell cycle arrest] GO:0007399 [nervous system development] GO:0030425 [dendrite] GO:0043025 [neuronal cell body] GO:0045666 [positive regulation of neuron differentiation] GO:0045786 [negative regulation of cell cycle] GO:0045930 [negative regulation of mitotic cell cycle] GO:0071300 [cellular response to retinoic acid] Show all	766 aa 88.4 kDa	Yes	0
BRINP3-003 ENSP00000393441 ENST00000445957	B1AMP1 [Direct mapping] BMP/retinoic acid-inducible neural-specific protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		28 aa 3.4 kDa	No	0
BRINP3-006 ENSP00000487601 ENST00000631494		MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		158 aa 18.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.