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Term
Gene name

Class

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Chromosome

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Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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KCNT2
  • TISSUE

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  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

Potassium channel, sodium activated subfamily T, member 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

HPA051218

Tissue

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Tissue

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A few cases of liver malignancies and occasional breast cancer displayed strong nuclear staining. Strong cytoplasmic staining was observed in a case of malignant carcinoid. Moderate positivity was observed in a few cases of prostate, endometrial, thyroid, liver and lung cancers. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

KCNT2 (HGNC Symbol)

Synonyms

KCa4.2, SLICK, SLO2.1

Description

Potassium channel, sodium activated subfamily T, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

q31.3

Chromosome location (bp)

196225779 - 196609225

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162687 (version 83.38)

Entrez gene

343450

UniProt

Q6UVM3 (UniProt - Evidence at protein level)

neXtProt

NX_Q6UVM3

Antibodypedia

KCNT2 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

KCNT2-001
KCNT2-002
KCNT2-006
KCNT2-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNT2-001
ENSP00000294725
ENST00000294725
Q6UVM3 [Direct mapping]
Potassium channel subfamily T member 2
A9LNM6 [Target identity:100%; Query identity:100%]
Sodium activated potassium channel
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Calcium-Activated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0071805 [potassium ion transmembrane transport]
Show all
1135 aa
130.5 kDa
No 6
KCNT2-002
ENSP00000356403
ENST00000367433
Q6UVM3 [Direct mapping]
Potassium channel subfamily T member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Calcium-Activated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0071805 [potassium ion transmembrane transport]
Show all
1111 aa
127.7 kDa
No 6
KCNT2-006
ENSP00000476657
ENST00000609185
Q6UVM3 [Direct mapping]
Potassium channel subfamily T member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Calcium-Activated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0071805 [potassium ion transmembrane transport]
Show all
1068 aa
122.6 kDa
No 6
KCNT2-201
ENSP00000405474
ENST00000451324
Q3SY61 [Direct mapping]
KCNT2 protein; Potassium channel subfamily T member 2
Show all
Predicted intracellular proteins
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0006813 [potassium ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016020 [membrane]
GO:0071805 [potassium ion transmembrane transport]
Show all
370 aa
41.9 kDa
No 0

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The Human Protein Atlas project is funded
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