Tissue expression of EXTL2 - Summary - The Human Protein Atlas

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EXTL2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EXTL2
Gene description	Exostosin-like glycosyltransferase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General granular cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. CAB020716
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	EXTL2
Synonyms
Description	Exostosin-like glycosyltransferase 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	100872372 - 100895998
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162694 (version 83.38)
Entrez gene	2135
UniProt	Q9UBQ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBQ6
Antibodypedia	EXTL2 antibodies

PROTEIN BROWSER

EXTL2-001	EXTL2-002	EXTL2-003	EXTL2-004	EXTL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXTL2-001 ENSP00000359132 ENST00000370114	Q9UBQ6 [Direct mapping] Exostosin-like 2 Processed exostosin-like 2 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001888 [glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0019276 [UDP-N-acetylgalactosamine metabolic process] GO:0035248 [alpha-1,4-N-acetylgalactosaminyltransferase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	330 aa 37.5 kDa	No	0
EXTL2-002 ENSP00000359131 ENST00000370113	Q9UBQ6 [Direct mapping] Exostosin-like 2 Processed exostosin-like 2 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001888 [glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0019276 [UDP-N-acetylgalactosamine metabolic process] GO:0035248 [alpha-1,4-N-acetylgalactosaminyltransferase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	330 aa 37.5 kDa	No	0
EXTL2-003 ENSP00000392255 ENST00000416479	C9IYF5 [Direct mapping] Exostosin-like 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	117 aa 13.3 kDa	Yes	0
EXTL2-004 ENSP00000403363 ENST00000450240	C9JEG3 [Direct mapping] Exostosin-like 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	266 aa 29.9 kDa	No	0
EXTL2-201 ENSP00000444385 ENST00000535414	F5GZK1 [Direct mapping] Exostosin-like 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006024 [glycosaminoglycan biosynthetic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] Show all	147 aa 16.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.