Expression of ARPC5 in cancer - Summary

CANCER ATLAS

Gene description

Actin related protein 2/3 complex, subunit 5, 16kDa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA022013

GENE INFORMATION
Gene name	ARPC5 (HGNC Symbol)
Synonyms	ARC16, dJ127C7.3, p16-Arc
Description	Actin related protein 2/3 complex, subunit 5, 16kDa (HGNC Symbol)
Entrez gene summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	1
Cytoband	q25.3
Chromosome location (bp)	183620846 - 183635757
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162704 (version 83.38)
Entrez gene	10092
UniProt	O15511 (UniProt - Evidence at protein level)
neXtProt	NX_O15511
Antibodypedia	ARPC5 antibodies

PROTEIN BROWSER

ARPC5-001	ARPC5-002	ARPC5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARPC5-001 ENSP00000352918 ENST00000359856	O15511 [Direct mapping] Actin-related protein 2/3 complex subunit 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0030036 [actin cytoskeleton organization] GO:0030833 [regulation of actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	151 aa 16.3 kDa	No	0
ARPC5-002 ENSP00000294742 ENST00000294742	O15511 [Direct mapping] Actin-related protein 2/3 complex subunit 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0030036 [actin cytoskeleton organization] GO:0030833 [regulation of actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995 [cell projection] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	154 aa 16.6 kDa	No	0
ARPC5-004 ENSP00000356504 ENST00000367534	B1ALC0 [Direct mapping] Actin-related protein 2/3 complex subunit 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005885 [Arp2/3 protein complex] GO:0015629 [actin cytoskeleton] GO:0030833 [regulation of actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] Show all	135 aa 14.8 kDa	No	0