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NLRP3

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GENERAL INFORMATION

Gene name

 NLRP3

Gene description

 NLR family, pyrin domain containing 3

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (THP-1, U-937)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NLRP3 (HGNC Symbol)

Synonyms

 AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1

Description

 NLR family, pyrin domain containing 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

Chromosome

 1

Cytoband

 q44

Chromosome location (bp)

 247416156 - 247449108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162711 (version 83.38)

Entrez gene

 114548

UniProt

 Q96P20 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96P20

Antibodypedia

 NLRP3 antibodies

PROTEIN BROWSER
NLRP3-001
NLRP3-002
NLRP3-003
NLRP3-004
NLRP3-007
NLRP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRP3-001
ENSP00000337383
ENST00000336119
Q96P20 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 3
A0A024R5Q0 [Target identity:100%; Query identity:100%]
Cold autoinflammatory syndrome 1, isoform CRA_b
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0009595 [detection of biotic stimulus]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032611 [interleukin-1 beta production]
GO:0032621 [interleukin-18 production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042834 [peptidoglycan binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044546 [NLRP3 inflammasome complex assembly]
GO:0045087 [innate immune response]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050701 [interleukin-1 secretion]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0050728 [negative regulation of inflammatory response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051607 [defense response to virus]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072559 [NLRP3 inflammasome complex]
GO:2000321 [positive regulation of T-helper 17 cell differentiation]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
Show all
 1036 aa
118.2 kDa 		No 0
NLRP3-002
ENSP00000294752
ENST00000348069
Q96P20 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 3
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0009595 [detection of biotic stimulus]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042834 [peptidoglycan binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072559 [NLRP3 inflammasome complex]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
Show all
 922 aa
106 kDa 		No 0
NLRP3-003
ENSP00000375704
ENST00000391828
Q96P20 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 3
A0A024R5Q0 [Target identity:100%; Query identity:100%]
Cold autoinflammatory syndrome 1, isoform CRA_b
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0009595 [detection of biotic stimulus]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042834 [peptidoglycan binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072559 [NLRP3 inflammasome complex]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
Show all
 1036 aa
118.2 kDa 		No 0
NLRP3-004
ENSP00000375703
ENST00000391827
Q96P20 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 3
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0009595 [detection of biotic stimulus]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042834 [peptidoglycan binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072559 [NLRP3 inflammasome complex]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
Show all
 979 aa
111.9 kDa 		No 0
NLRP3-007
ENSP00000355452
ENST00000366496
Q96P20 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 3
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0009595 [detection of biotic stimulus]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042834 [peptidoglycan binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072559 [NLRP3 inflammasome complex]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
Show all
 979 aa
112.3 kDa 		No 0
NLRP3-201
ENSP00000355453
ENST00000366497
Q96P20 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 3
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Show all
GO:0002674 [negative regulation of acute inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0009595 [detection of biotic stimulus]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042347 [negative regulation of NF-kappaB import into nucleus]
GO:0042834 [peptidoglycan binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0072559 [NLRP3 inflammasome complex]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
Show all
 979 aa
112.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.