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KCNJ9

GENERAL INFORMATION

Gene name

 KCNJ9

Gene description

 Potassium channel, inwardly rectifying subfamily J, member 9

Protein class

 Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus, hypothalamus, caudate)
FANTOM5:Group enriched (cerebellum, hippocampus, brain, caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA070478
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Appendix
N/A
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, cerebral cortex, hippocampus, hypothalamus, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, hippocampus, brain, caudate)

GENE INFORMATION

Gene name

 KCNJ9 (HGNC Symbol)

Synonyms

 GIRK3, Kir3.3

Description

 Potassium channel, inwardly rectifying subfamily J, member 9 (HGNC Symbol)

Entrez gene summary

 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 160081570 - 160090563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162728 (version 83.38)

Entrez gene

 3765

UniProt

 Q92806 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92806

Antibodypedia

 KCNJ9 antibodies

PROTEIN BROWSER
KCNJ9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNJ9-001
ENSP00000357067
ENST00000368088
Q92806 [Direct mapping]
G protein-activated inward rectifier potassium channel 3
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Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005242 [inward rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0010107 [potassium ion import]
GO:0015467 [G-protein activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
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 393 aa
44 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.